Blocking of Hog Intrinsic Factor by Human Gastric Juice and Certain Mucopolysaccharides , in - Cluding Blood
نویسنده
چکیده
Intrinsic factor can bind vitamin B12 and simultaneously attach to receptors on liver or small intestine in a calcium-dependent manner (1). There appears to be a stoichiometric relationship between the receptors, intrinsic factor and vitamin B12 (2). This report, previously presented in preliminary form (3), is concerned with blocking of the receptor sites for hog intrinsic factor by human gastric juice and certain mucopolysaccharides, including blood group substance.
منابع مشابه
Blocking of hog intrinsic factor by human gastric juice and certain mucopolysaccharides, including blood group substance.
Intrinsic factor can bind vitamin B12 and simultaneously attach to receptors on liver or small intestine in a calcium-dependent manner (1). There appears to be a stoichiometric relationship between the receptors, intrinsic factor and vitamin B12 (2). This report, previously presented in preliminary form (3), is concerned with blocking of the receptor sites for hog intrinsic factor by human gast...
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The binding of vitamin B(12) by human gastric juice has been found to be pH dependent. Maximum binding occurs between pH 6.5 and 10. Outside this pH range the vitamin B(12)-binding ability of human gastric juice decreases and at pH below 2 or above 12.2 this drops sharply to about 10 to 15% of the maximum. Three commercial hog intrinsic factors have been found to give a similar response to pH c...
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